Enterovirus D68 is linked to rare cases of the polio-like illness acute myelitis, or AFM. So far this year, the CDC has confirmed 13 cases of AFM. <\/p>\n\n\n\n
A\u2002respiratory virus that sometimes paralyzes children<\/a> is spreading across the U.S., raising concerns about another possible rise in polio-like illnesses.<\/p>\n\n\n\n Wastewater samples<\/a> have detected a significant escalation in an enterovirus called D68, which, in rare cases, has been linked to acute flaccid myelitis, or AFM. The illness affects the nervous system and causes severe weakness in the arms and legs. This most often occurs in young children. <\/p>\n\n\n\n \u201cWe are detecting EV-D68 nucleic acids in wastewater across the country now, and the levels are increasing,\u201d said Alexandria Boehm, program director of WastewaterSCAN<\/a>, a nonprofit monitoring network and a professor of civil and environmental engineering at Stanford University.<\/p>\n\n\n\n That\u2019s the first clue to suggest that the nation might see an increase in AFM this year, said Caitlin Rivers, an epidemiologist at the Johns Hopkins Center for Health Security and author of \u201cCrisis Averted: The Hidden Science of Fighting Outbreaks.\u201d<\/p>\n\n\n\n \u201cThe second clue,\u201d she said, \u201cis that the time of year is right.\u201d<\/p>\n\n\n\n Historically, September has been the biggest month for AFM cases.<\/p>\n\n\n\n Anyone who\u2019s ever had the sniffles probably had an enterovirus; they\u2019re that common. Most of the time, the viruses cause mild symptoms, such as a runny nose, cough, headache and generalized feelings of “meh.”<\/p>\n\n\n\n The D68 enterovirus strain started causing more serious problems in 2014, when the U.S. saw, for the first time, a spike in pediatric AFM. That year, 120 kids were diagnosed.<\/p>\n\n\n\n There’s no cure or specific treatment for the paralysis. Even with years of intensive physical therapy, many are left with life-altering disabilities.<\/p>\n\n\n\n Though a few dozen cases have been reported every year since then,\u2002larger waves of AFM have followed an every-other-year pattern<\/a>, spiking again in 2016 (with 153 cases) and in 2018 (with 238 cases).<\/p>\n\n\n\n The pattern stopped in 2020 when the nation went into lockdown because of the Covid pandemic, drastically reducing viral spread. That year, just 32 cases were logged. The spread of D68 picked up again in 2022 as lockdowns were lifted.<\/p>\n\n\n\n Curiously, a rise in AFM cases didn\u2019t follow.<\/p>\n\n\n\n \u201cWe saw the virus that was previously driving the AFM cases, but we didn\u2019t see the AFM cases associated with it,\u201d said Dr. Kevin Messacar, an infectious disease specialist at Children\u2019s Hospital Colorado, who treated some of the earliest AFM cases in 2014.<\/p>\n\n\n\n It\u2019s a mystery that any virologist would appreciate. While experts try to predict how viruses will behave, the bugs are always working to stay a few steps ahead.<\/p>\n\n\n\n It could be that the virus itself has changed, or that more people in the U.S. have been exposed and now have a level of immunity to D68. \u201cWe\u2019re still trying to figure it out,\u201d Messacar said.<\/p>\n\n\n\n So far in 2024, 13 AFM cases have been confirmed, according to the Centers for Disease Control and Prevention. Since 2014, 758 cases have been logged.<\/p>\n\n\n\n The implication is that hundreds of families and their children have been left with lasting, life-altering paralysis because of a virus.<\/p>\n\n\n\n The Kagolanu family in Los Altos, California, was in a heated game of Monopoly one Friday night in November 2014 when 7-year-old Vishnu’s head began, inexplicably, to tilt to one side. Vishnu admits that even though he was losing the game, this wasn’t attention-seeking behavior.<\/p>\n\n\n\n “My dad was like, ‘Hey, what are you doing? Move your head back straight,'” Vishnu, now 17, said. “I just thought, I can’t do that.”<\/p>\n\n\n\n Within an hour, Vishnu lost all ability to move his arms and legs. “I couldn’t get myself off the floor,” he said.<\/p>\n\n\n\n Vishnu was one of the first to be diagnosed with AFM in 2014. At that time, no one had connected the dots between D68 and the “mystery illness<\/a>.”<\/p>\n\n\n\n “We didn\u2019t understand what was going on. Even the doctors couldn\u2019t find out what was going on,” said Saila Kagolanu, Vishnu’s mother. “That was the worst experience of my life.”<\/p>\n\n\n\n Doctors warned Vishnu’s family that he might never regain function of his arms and legs. The poor prognosis crushed Vishnu. He’d always thrived as “king of the playground” when it came to sports and other physical activities.<\/p>\n\n\n\n “Seeing my legs go progressively smaller every day” was devastating, he said. “I couldn\u2019t move.”<\/p>\n\n\n\n Vishnu spent years undergoing physical therapy to regain the ability to walk. That was successful. Otherwise, there\u2019s not much doctors can do. His right shoulder remains limp.<\/p>\n\n\n\n \u201cWe all get really frustrated every time we get to this point, and we don\u2019t have antiviral medicines that are readily available,\u201d said Dr. Buddy Creech, a pediatric infectious disease physician at Vanderbilt University Medical Center in Nashville. \u201cWe don\u2019t have much to offer these kids.\u201d<\/p>\n\n\n\n Creech and his colleagues are working toward a solution. They\u2019ve begun safety studies of a monoclonal antibody that would, ideally, stop D68 in its tracks.<\/p>\n\n\n\n \u201cIn mouse studies, it prevented infection that would lead to AFM,\u201d Creech said. The study is expected to take years before the treatment is considered safe and effective.<\/p>\n\n\n\n Meanwhile, young people like Vishnu Kagolanu are attempting to move on and even inspire others with AFM. In recent years, he started a nonprofit called Neurostronger<\/a>, which works to raise funds for and increase awareness of kids with neurologic conditions.<\/p>\n\n\n\n \u201cGrowing up with AFM is hard,\u201d Kagolanu said. \u201cBut at the same time, there are ways to get around some of those obstacles. There are ways to find joy.\u201d<\/p>\n\n\n\nA viral mystery<\/strong><\/strong><\/h2>\n\n\n\n
Some recovery after years of physical therapy<\/strong><\/strong><\/h2>\n\n\n\n
Testing a possible treatment<\/strong><\/strong><\/h2>\n\n\n\n